About Enhancer
| Enhancer ID: | E_01_151 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr13:95865319-95866199   |
|
| Biosample name: | Umbilical Vein Endothelial Cell,ESCC | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer | |
| Disease: | Esophageal Squamous Cell Carcinoma | |
| DO: | -- | |
| Mesh: | D000077277 | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 24510239 |
| Enhancer experiment: | Luciferase Reporter Assay | |
| Enhancer experiment description: | Luciferase reporter gene assays verified that the ABCC4 intron 4 sequence, which was annotated as an enhancer element by ENCODE(chr13: 94,663,320-94,664,200), also exhibited enhancer activity in multiple cancer cell types.However,the resulting intensities were much higher in two ESCC cells, KYSE140 and EC0156，which suggests that the enhancer activity within this region is rela_x0002_tively specific to ESCC. |
About Target gene
| Target gene : | ABCC4(MOAT-B,MOATB,MRP4) | |
| Strong evidence: | -- | |
| Less strong evidence: | Luciferase Reporter Assay | |
| Target gene experiment description: | GRAIL analysis highlighted potential cancer-associated func_x0002_tions of the genes from the four CNV regions with frequencies >5%.ABCC4 had strong associations with transport regulation, immunol_x0002_ogy and multiple cancer-related signaling pathways.Furthermore, conditional logistic regression analysis showed that variations in ABCC4copy number were associated with ESCC after adjusting for age, sex and lifestyle. |
About TF
| TF name : | CRE(CRE) | |
| TF experiment: | Western blot | |
| TF experiment description: | Western blot analysis showed that ABCC4 was effectively depleted following siRNA transfection. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
