About Enhancer
| Enhancer ID: | E_01_121 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr11:8301851-8303851   |
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| Biosample name: | T-acute lymphoblastic leukemia (T-ALL) | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer | |
| Disease: | T-Cell leukemia | |
| DO: | DOID:715 | |
| Mesh: | D015458 | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 23302769 |
| Enhancer experiment: | ChIP,RT-PCR,Luciferase Reporter Assay | |
| Enhancer experiment description: | The LMO1 promoters display bivalent histone marks in multiple blood lineages including T-cells, and a 3’ flanking region at LMO1 þ 57 contains a transcriptional enhancer that is active in developing blood cells in transgenic mouse embryos. The LMO1 promoters become activated in T-ALL together with the 3’ enhancer, which is bound in primary T-ALL cells by SCL/TAL1 and GATA3. |
About Target gene
| Target gene : | LMO1(RBTN1,RHOM1,TTG1) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP,RT-PCR,Luciferase Reporter Assay | |
| Target gene experiment description: | To investigate whether lack of expres_x0002_sion in the haematopoietic system may be due to active repression of the two LMO1 promoters, we analysed ChIP-Sequencing data released to the public domain by the NIH Roadmap Epigeno_x0002_mics Mapping Project. |
About TF
| TF name : | TAL1(SCL,TCL5,bHLHa17,tal-1)GATA3(HDR,HDRS) | |
| TF experiment: | ChIP,qPCR | |
| TF experiment description: | ChIP assays on T-ALL cells from the same primagraft (X31) using antibodies against SCL/TAL1and GATA3. Analysis by quantitative PCR demonstrates significant binding of both SCL/TAL1 and GATA3 to the LMO1 +57 enhancer, with no binding to either of the two LMO1 promoters. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
