About Enhancer
| Enhancer ID: | E_01_076 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr1:33353796-33354196   |
|
| Biosample name: | HC11 Mammary Epithelium | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 21527503 |
| Enhancer experiment: | Luciferase Reporter Assay,PCR,ChIP | |
| Enhancer experiment description: | As detected by chromatin immunoprecipitation assays, treatment of cells with the progestin agonist R5020 induced a rapid recruitment (5 min) of PR to the proximal promoter (−235 bp) and distal enhancer (−6 kb upstream of transcription start site) of β-casein |
About Target gene
| Target gene : | TMEM54(BCLP,CAC-1,CAC1),β-casein gene | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP | |
| Target gene experiment description: | In this study, we used HC-11 cells and ChIP assays to examine the influence of progesterone and PR on cooperative interactions and dynamics of the various transcription factors and coregulatory proteins that interact with the promoter and enhancer of the endogenous β-casein gene. |
About TF
| TF name : | STAT5B(STAT5)CEBPB(C/EBP-beta,IL6DBP,NF-IL6,TCF5)YY1(DELTA,GADEVS,INO80S,NF-E1,UCRBP,YIN-YANG-1) | |
| TF experiment: | PCR,ChIP | |
| TF experiment description: | Primers for PCR amplification of the proximal promoter span a 170-bp region (-190 to -20 from the transcription start site) containing binding sites for Stat5a,C/EBP,YY1,and GRE/progestin response element (PRE) half-sites, whereas a 400-bp region (-6400 to -6000) of the distal Enhancer was amplified that contains binding sites for Stat5,C/EBP,and other factors. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
