About Enhancer
| Enhancer ID: |
|
E_01_049 |
| Enhancer symbol: |
|
-- |
| Species: |
|
Human |
| Position : |
|
chr12:100693355-100695355
   |
| Biosample name: |
|
MCF-7 |
| Experiment class : |
|
Low throughput |
| Enhancer type: |
|
Enhancer |
| Disease: |
|
-- |
| DO: |
|
-- |
| Mesh: |
|
-- |
| Distance from TSS: |
|
>2KB |
| Pubmed ID: |
|
21348942 |
| Enhancer experiment: |
|
ChIP,Western blot,siRNA,qPCR |
| Enhancer experiment description: |
|
The reaction was performed at a combined annealing/extension temperature of 60 °C for 40 cycles using primers designed to specifically amplify the sequence containing the +571 ERE half‐site and two regions covering ER‐binding sites named enhancer 1 and enhancer 2 located at −168 and −206 kb in the PR regulatory regions. |
About Target gene
| Target gene : |
|
RB1(OSRC,PPP1R130,RB,p105-Rb,pRb,pp110) |
| Strong evidence: |
|
-- |
| Less strong evidence: |
|
ChIP |
| Target gene experiment description: |
|
ChIP analysis of PR regulatory regions in MCF--7 cells.Distal ER--binding sites and a proximal half--ERE located 571 bp downstream of the PRB tsp are highlighted with black diamonds. |
About TF
| TF name : |
|
KDM5A(RBBP-2,RBBP2,RBP2) |
| TF experiment: |
|
Western blot |
| TF experiment description: |
|
Overexpression of the wild-type and mutated JARID1A forms after transfection of the corresponding plasmids in MCF-7 cells was confirmed at the protein level by western blot analysis. |
About Function
| Enhancer function : |
-- |
| Enhancer function experiment: |
-- |
Enhancer function
experiment description: |
-- |
About SNP
| SNP ID: |
|
-- |
| SNP position: |
|
-- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
Expression of target genes for the enhancer
Enhancer associated SNPs
