About Enhancer
| Enhancer ID: | E_01_039 | |
| Enhancer symbol: | FKBP51 Enhancer | |
| Species: | Human | |
| Position : | chr6:35505138-35511492   |
|
| Biosample name: | A549,VCaP | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 20093418 |
| Enhancer experiment: | RT-qPCR,ChIP | |
| Enhancer experiment description: | According to our quantitative ChIP and enhancer assays, there are at least three major distal gene regions that significantly bind GR and also function as strong GR-regulated enhancers in isolation. |
About Target gene
| Target gene : | FKBP4(FKBP51,FKBP52,FKBP59,HBI,Hsp56,PPIase,p52) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP,Luciferase Reporter Assay | |
| Target gene experiment description: | Our quantitative chromatin immunoprecipitation scans and enhancer activity analyses indicate that activation of the FKBP51 locus by glucocorticoids in vivo is triggered by the loading of GR to enhancers at about 34 kb 5 and about 87 kb 3 of the transcription start site. |
About TF
| TF name : | CTCF(MRD21) | |
| TF experiment: | ChIP | |
| TF experiment description: | Interestingly,our ChIP assays from the A549 cells indicate a significant enrichment of both the CTCF and the cohesin subunit RAD21 at regions approximately 48 kb 5' and about 105kb 3' of the FKBP51 TSS, which border the region en_x0002_compassing the GR-regulated Enhancers. |
About Function
| Enhancer function : | The holo-GR is capable of activating transcription and evoking changes in chromatin structure through distant-acting Enhancers. |
| Enhancer function experiment: | ChIP |
| Enhancer function experiment description: |
Our quantitative chromatin immunoprecipitation scans and Enhancer activity analyses indicate that activation of the FKBP51 locus by glucocorticoids in vivo is triggered by the loading of GR to Enhancers at about 34 kb 5' and about 87 kb 3' of the transcription start site. |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
