About Enhancer
| Enhancer ID: | E_05249 |
| Species: | Homo sapiens |
| Position : | chr8:129546728-129712179   |
| Year: | 2019 |
| Title: | Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell acute lymphoblastic leukemia |
| PMID: | 31127282 |
| MONDO: | MONDO:0004947 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | SEM B-ALL cells |
| Cell Type: | B-lymphoblast/precursor B cell |
| Experiment Type: | Acute architectural-factor depletion; enhancer-promoter interaction analysis; target-gene response |
| High Throughput Method: | RNA-seq; Hi-C/chromosome-conformation profiling; CTCF chromatin profiling |
| Low Throughput Method: | Auxin-inducible CTCF degradation; targeted chromatin-conformation assay; RT-qPCR; Western blot |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
Expression of Target Genes for the Enhancer