About Enhancer
| Enhancer ID: | E_05235 |
| Species: | Mus musculus |
| Position : | chr11:44390063-44390123   |
| Year: | 2013 |
| Title: | Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 23154183 |
| Cell Source: | HEK-293 |
| CVCL ID: | CVCL_0045 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | Il12b |
About TF
| TF name : | Irf4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Irf4 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Irf4 | IL4-mediated signaling events | pid | 66 |
| Irf4 | Interferon alpha/beta signaling | reactome | 67 |
| Irf4 | Interferon gamma signaling | reactome | 88 |
| Irf4 | Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 | wikipathways | 71 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_05348 | chr11:44386118-44393090 | NA | macrophage | Inflammatory Disease |
| E_02929 | chr11:44389500-44390500 | blood | macrophage | NA |
| E_02793 | chr11:44390069-44390173 | ascitic fluid | macrophage | NA |
| E_02833 | chr11:44390069-44390173 | bone marrow | macrophage | NA |
| E_02874 | chr11:44390069-44390173 | peritoneal cavity | macrophage | NA |
| E_02723 | chr11:44390082-44390626 | bone marrow | macrophage | NA |
Expression of Target Genes for the Enhancer