About Enhancer
| Enhancer ID: | E_03508 |
| Species: | Homo sapiens |
| Position : | chr3:128322357-128323157   |
| Year: | 2021 |
| Title: | Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | MECOM-rearranged acute myeloid leukemia |
| PMID: | 33911178 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | MUTZ-3 |
| CVCL ID: | CVCL_1433 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | TF-complex dissection at a hijacked enhancer; enhancer-promoter interaction; functional TF perturbation |
| High Throughput Method: | CEBPA ChIP-seq; RUNX1/CEBPA ChIP-SICAP; RNA-seq; 4C-seq |
| Low Throughput Method: | Luciferase assay; TF-site mutagenesis; TF knockdown/perturbation; RT-qPCR |
About Target Gene
| Target gene : | MECOM |
About TF
| TF name : | ELK1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ELK1 | Angiopoietin receptor Tie2-mediated signaling | pid | 50 |
| ELK1 | Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin | panther | 34 |
| ELK1 | BCR | netpath | 161 |
| ELK1 | BCR signaling pathway | pid | 70 |
| ELK1 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| ELK1 | EGFR1 | netpath | 475 |
| ELK1 | ErbB1 downstream signaling | pid | 105 |
| ELK1 | ERK cascade ( EGF signaling pathway Diagram ) | inoh | 6 |
| ELK1 | ERK cascade ( FGF signaling pathway ) | inoh | 8 |
| ELK1 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| ELK1 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| ELK1 | ERK cascade ( HGF signaling pathway ) | inoh | 6 |
| ELK1 | ERK cascade ( IGF1 signaling pathway ) | inoh | 8 |
| ELK1 | ERK cascade ( Insulin receptor signaling (D. melanogaster) ) | inoh | 8 |
| ELK1 | ERK cascade ( Insulin receptor signaling (Mammal) ) | inoh | 8 |
| ELK1 | ERK cascade ( NGF signaling pathway ) | inoh | 8 |
| ELK1 | ERK cascade ( VEGF signaling pathway ) | inoh | 6 |
| ELK1 | ERK/MAPK targets | reactome | 17 |
| ELK1 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| ELK1 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| ELK1 | HIF-2-alpha transcription factor network | pid | 34 |
| ELK1 | ID | netpath | 38 |
| ELK1 | IL2 | netpath | 81 |
| ELK1 | IL4 | netpath | 75 |
| ELK1 | IL5 | netpath | 59 |
| ELK1 | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | panther | 29 |
| ELK1 | Interleukin signaling pathway | panther | 86 |
| ELK1 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | smpdb | 37 |
| ELK1 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | smpdb | 38 |
| ELK1 | KitReceptor | netpath | 104 |
| ELK1 | Leptin | netpath | 98 |
| ELK1 | Oxidative stress response | panther | 23 |
| ELK1 | p38 MAPK pathway | panther | 31 |
| ELK1 | Parkinson disease | panther | 85 |
| ELK1 | PDGF signaling pathway | panther | 113 |
| ELK1 | PDGFR-alpha signaling pathway | pid | 22 |
| ELK1 | PDGFR-beta signaling pathway | pid | 125 |
| ELK1 | Prolactin | netpath | 105 |
| ELK1 | Ras Pathway | panther | 69 |
| ELK1 | Ras signaling in the CD4+ TCR pathway | pid | 14 |
| ELK1 | S1P2 pathway | pid | 26 |
| ELK1 | Toll receptor signaling pathway | panther | 44 |
| ELK1 | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| ELK1 | ERK cascade ( PDGF signaling pathway ) | inoh | 7 |
| ELK1 | MAPK signaling pathway | kegg | 264 |
| ELK1 | ErbB signaling pathway | kegg | 83 |
| ELK1 | Focal adhesion | kegg | 197 |
| ELK1 | Insulin signaling pathway | kegg | 134 |
| ELK1 | GnRH signaling pathway | kegg | 98 |
| ELK1 | Prion diseases | kegg | 34 |
| ELK1 | Leishmaniasis | kegg | 71 |
| ELK1 | Endometrial cancer | kegg | 52 |
| ELK1 | Hs_Cytokines_and_Inflammatory_Response_WP530_79331 | wikipathways | 21 |
| ELK1 | Hs_MAPK_Signaling_Pathway_WP382_79951 | wikipathways | 58 |
| ELK1 | Hs_Leptin_signaling_pathway_WP2034_89856 | wikipathways | 37 |
| ELK1 | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| ELK1 | Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707 | wikipathways | 34 |
| ELK1 | Hs_Estrogen_signaling_pathway_WP712_78491 | wikipathways | 13 |
| ELK1 | Hs_G_Protein_Signaling_Pathways_WP35_88601 | wikipathways | 8 |
| ELK1 | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
| ELK1 | Hs_IL-5_Signaling_Pathway_WP127_78498 | wikipathways | 35 |
| ELK1 | Hs_IL-4_Signaling_Pathway_WP395_89828 | wikipathways | 41 |
| ELK1 | Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 | wikipathways | 80 |
| ELK1 | Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 | wikipathways | 107 |
| ELK1 | Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 | wikipathways | 71 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
41 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03426 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03427 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03428 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03429 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03430 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03431 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03504 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03505 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03506 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03507 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03509 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03510 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03511 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03512 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03513 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03514 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03515 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03516 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03517 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03518 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03519 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03520 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03521 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03522 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03523 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03524 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_01351 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [inv(3)(q21;q26.2)/t(3;3)(q21;q26.2)] |
| E_01372 | chr3:128322411-128323124 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01373 | chr3:128322411-128323124 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_01382 | chr3:128322411-128323124 | peripheral blood | AML hematopoietic progenitor-like leukemia cell | acute myeloid leukemia |
| E_01383 | chr3:128322411-128323124 | bone marrow | malignant cell | acute myeloid leukemia |
| E_01394 | chr3:128322411-128323124 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01395 | chr3:128322411-128323124 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_01396 | chr3:128322411-128323124 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01397 | chr3:128322411-128323124 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_01403 | chr3:128322411-128323124 | peripheral blood | AML hematopoietic progenitor-like leukemia cell | acute myeloid leukemia |
| E_01404 | chr3:128322411-128323124 | peripheral blood | AML hematopoietic progenitor-like leukemia cell | acute myeloid leukemia |
| E_03530 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
| E_03531 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
| E_03532 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
| E_03533 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
Expression of Target Genes for the Enhancer