About Enhancer
| Enhancer ID: | E_03394 |
| Species: | Mus musculus |
| Position : | chr7:126416668-126416932   |
| Year: | 2008 |
| Title: | Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 18552207 |
| Tissue: | spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | Primary splenic B cells |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | TF binding assay; Chromatin accessibility assay; Enhancer-state assay |
| Low Throughput Method: | DNase I hypersensitivity assay; Southern blot; ChIP; in vivo DMS footprinting; LM-PCR; bisulfite sequencing |
About Target Gene
| Target gene : | Cd19 |
About TF
| TF name : | Tcf3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tcf3 | CDO in myogenesis | reactome | 29 |
| Tcf3 | ID | netpath | 38 |
| Tcf3 | Notch-mediated HES/HEY network | pid | 48 |
| Tcf3 | Notch | netpath | 76 |
| Tcf3 | p38 signaling mediated by MAPKAP kinases | pid | 21 |
| Tcf3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Tcf3 | Wnt | netpath | 118 |
| Tcf3 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03392 | chr7:126416668-126416932 | bone marrow | hematopoietic multipotent progenitor cell | NA |
| E_03393 | chr7:126416668-126416932 | bone marrow | pro-B cell | NA |
| E_03395 | chr7:126416668-126416932 | thymus | T cell | NA |
| E_03407 | chr7:126416668-126416932 | spleen | B cell | NA |
| E_03408 | chr7:126416668-126416932 | spleen | B cell | NA |
Expression of Target Genes for the Enhancer