Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_03392
Species: Mus musculus
Position : chr7:126416668-126416932
Year: 2008
Title: Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus.
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
PMID:  18552207
Tissue: bone marrow
Tissue Ontology ID: UBERON:0002371
Cell Source: Primary multipotent hematopoietic progenitors
Cell Type: hematopoietic multipotent progenitor cell
Cell Ontology ID: CL:0000837
Experiment Type: Epigenetic priming assay; TF binding assay; Chromatin accessibility assay
Low Throughput Method: Cell sorting; DNase I hypersensitivity assay; ChIP; bisulfite sequencing; in vivo DMS footprinting; LM-PCR
About Target Gene
Target gene : Cd19
About TF
TF name : Tcf3
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Tcf3 CDO in myogenesis reactome 29
Tcf3 ID netpath 38
Tcf3 Notch-mediated HES/HEY network pid 48
Tcf3 Notch netpath 76
Tcf3 p38 signaling mediated by MAPKAP kinases pid 21
Tcf3 Regulation of nuclear SMAD2/3 signaling pid 82
Tcf3 Wnt netpath 118
Tcf3 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
Enhancer Associated Network
Overlapping Enhancers (mm10) 5 found
Enhancer ID Position Tissue Cell Disease
E_03393 chr7:126416668-126416932 bone marrow pro-B cell NA
E_03394 chr7:126416668-126416932 spleen B cell NA
E_03395 chr7:126416668-126416932 thymus T cell NA
E_03407 chr7:126416668-126416932 spleen B cell NA
E_03408 chr7:126416668-126416932 spleen B cell NA
Expression of Target Genes for the Enhancer