About Enhancer
| Enhancer ID: | E_03389 |
| Species: | Mus musculus |
| Position : | chr7:35912057-35912683   |
| Year: | 2019 |
| Title: | HoxA9 binds and represses the Cebpa +8 kb enhancer. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 31120998 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | 32Dcl3 |
| CVCL ID: | CVCL_0119 |
| Cell Type: | myeloid progenitor cell |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | HoxA9 ChIP-seq; ChIP-seq |
| Low Throughput Method: | EMSA; HoxA9-binding-site mutagenesis; luciferase reporter assay; HoxA9-ER activation; RT-qPCR; cycloheximide test |
About Target Gene
| Target gene : | Cebpa |
About TF
| TF name : | Hoxa9 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Hoxa9 | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (mm9)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03403 | chr7:35912057-35912683 | bone marrow | myeloid progenitor cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer