About Enhancer
| Enhancer ID: | E_03362 |
| Species: | Mus musculus |
| Position : | chr7:46351197-46355693   |
| Year: | 2015 |
| Title: | Wnt3a signal pathways activate MyoD expression by targeting cis-elements inside and outside its distal enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25651906 |
| Cell Source: | C2C12 |
| CVCL ID: | CVCL_0188 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; RT-qPCR/qPCR; Western blot |
About Target Gene
| Target gene : | Myod1 |
About TF
| TF name : | Wnt3a |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Wnt3a | Alzheimer disease-presenilin pathway | panther | 98 |
| Wnt3a | Cadherin signaling pathway | panther | 147 |
| Wnt3a | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| Wnt3a | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| Wnt3a | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| Wnt3a | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| Wnt3a | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| Wnt3a | Canonical Wnt signaling pathway | pid | 21 |
| Wnt3a | Class B/2 (Secretin family receptors) | reactome | 47 |
| Wnt3a | Degradation of beta catenin | pid | 18 |
| Wnt3a | Disassembly of the destruction complex and recruitment of AXIN to the membrane | reactome | 31 |
| Wnt3a | Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) | inoh | 228 |
| Wnt3a | Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) | inoh | 239 |
| Wnt3a | Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) | inoh | 237 |
| Wnt3a | Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) | inoh | 227 |
| Wnt3a | Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) | inoh | 228 |
| Wnt3a | Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) | inoh | 227 |
| Wnt3a | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| Wnt3a | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | reactome | 15 |
| Wnt3a | Noncanonical Wnt signaling pathway | pid | 33 |
| Wnt3a | Regulation of FZD by ubiquitination | reactome | 21 |
| Wnt3a | RNF mutants show enhanced WNT signaling and proliferation | reactome | 8 |
| Wnt3a | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| Wnt3a | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| Wnt3a | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| Wnt3a | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Wnt3a | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| Wnt3a | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Wnt3a | TCF dependent signaling in response to WNT | reactome | 31 |
| Wnt3a | Wnt | netpath | 118 |
| Wnt3a | WNT ligand biogenesis and trafficking | reactome | 26 |
| Wnt3a | Wnt secretory pathway (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 19 |
| Wnt3a | Wnt secretory pathway (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 19 |
| Wnt3a | Wnt secretory pathway (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 19 |
| Wnt3a | Wnt secretory pathway (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 19 |
| Wnt3a | Wnt secretory pathway (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| Wnt3a | Wnt secretory pathway (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 19 |
| Wnt3a | Wnt signaling network | pid | 29 |
| Wnt3a | Wnt signaling pathway | panther | 250 |
| Wnt3a | Xenopus axis formation Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 28 |
| Wnt3a | Hedgehog signaling pathway | kegg | 53 |
| Wnt3a | Melanogenesis | kegg | 100 |
| Wnt3a | Pathways in cancer | kegg | 321 |
| Wnt3a | Basal cell carcinoma | kegg | 51 |
| Wnt3a | Hs_Gene_regulatory_network_modelling_somitogenesis_WP2854_87527 | wikipathways | 12 |
| Wnt3a | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
Expression of Target Genes for the Enhancer