About Enhancer
| Enhancer ID: | E_03319 |
| Species: | Mus musculus |
| Position : | chr1:107667300-107677300   |
| Year: | 2024 |
| Title: | Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | traumatic proliferative vitreoretinopathy |
| PMID: | 39183203 |
| MONDO: | MONDO:0700115 |
| Tissue: | pigmented layer of retina |
| Tissue Ontology ID: | UBERON:0001782 |
| Cell Source: | Primary retinal pigment epithelial cells from traumatic PVR and contralateral control eyes of 8-week-old male C57BL/6J mice |
| Cell Type: | retinal pigment epithelial cell |
| Cell Ontology ID: | CL:0002586 |
| Experiment Type: | Enhancer characterization; Disease-associated chromatin profiling; Functional pathway perturbation assay |
| High Throughput Method: | ATAC-seq; H3K27ac ChIP-seq; H3K4me1 ChIP-seq; RNA-seq |
| Low Throughput Method: | OPG-Fc-mediated RANKL blockade; RT-qPCR; Western blot; Immunofluorescence; H&E staining; Fundus imaging; OCT |
About Target Gene
| Target gene : | Tnfrsf11a |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm9)
No overlapping enhancers found in mm9 at this locus.
Expression of Target Genes for the Enhancer