About Enhancer
| Enhancer ID: | E_03303 |
| Species: | Mus musculus |
| Position : | chr11:10077283-10077800   |
| Year: | 2020 |
| Title: | The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 32321991 |
| Tissue: | mammary gland |
| Tissue Ontology ID: | UBERON:0001911 |
| Cell Source: | Primary Mouse Mammary Epithelial |
| Cell Type: | mouse mammary epithelial cell |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq |
| Low Throughput Method: | CRISPR Knockout; CRISPRi; RT-RT-qPCR |
About Target Gene
| Target gene : | Wap |
About TF
| TF name : | Nfib |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Nfib | FOXA1 transcription factor network | pid | 45 |
| Nfib | RNA Polymerase III Abortive And Retractive Initiation | reactome | 41 |
| Nfib | RNA Polymerase III Transcription Termination | reactome | 23 |
| Nfib | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03309 | chr11:10070908-10082508 | mammary gland | mouse mammary epithelial cell | NA |
| E_03310 | chr11:10070908-10082508 | mammary gland | mouse mammary epithelial cell | NA |
| E_03311 | chr11:10070908-10082508 | mammary gland | mouse mammary epithelial cell | NA |
| E_03304 | chr11:10077283-10077800 | mammary gland | mouse mammary epithelial cell | NA |
| E_03305 | chr11:10077283-10077800 | mammary gland | mouse mammary epithelial cell | NA |
Expression of Target Genes for the Enhancer