About Enhancer
| Enhancer ID: | E_03283 |
| Species: | Mus musculus |
| Position : | chr18:87758000-87762000   |
| Year: | 2024 |
| Title: | Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | proliferative vitreoretinopathy |
| PMID: | 39183203 |
| MONDO: | MONDO:0700115 |
| Tissue: | retina |
| Tissue Ontology ID: | UBERON:0000966 |
| Cell Source: | Primary retinal pigment epithelium (RPE) cells |
| Cell Type: | retinal pigment epithelial cell |
| Cell Ontology ID: | CL:0002586 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ATAC-seq; ChIP-seq; RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR; RT-RT-qPCR; Western blot; CRISPRi (shRNA); Immunofluorescence |
About Target Gene
| Target gene : | Nfatc1 |
About TF
| TF name : | Tgif1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tgif1 | AndrogenReceptor | netpath | 167 |
| Tgif1 | Coregulation of Androgen receptor activity | pid | 61 |
| Tgif1 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | reactome | 23 |
| Tgif1 | EGFR1 | netpath | 475 |
| Tgif1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Tgif1 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | reactome | 32 |
| Tgif1 | TGF_beta_Receptor | netpath | 220 |
| Tgif1 | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
| Tgif1 | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03279 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03280 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03281 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03282 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
Expression of Target Genes for the Enhancer