About Enhancer
| Enhancer ID: | E_03281 |
| Species: | Mus musculus |
| Position : | chr18:87758000-87762000   |
| Year: | 2024 |
| Title: | Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | proliferative vitreoretinopathy |
| PMID: | 39183203 |
| MONDO: | MONDO:0700115 |
| Tissue: | retina |
| Tissue Ontology ID: | UBERON:0000966 |
| Cell Source: | Primary retinal pigment epithelium (RPE) cells |
| Cell Type: | retinal pigment epithelial cell |
| Cell Ontology ID: | CL:0002586 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ATAC-seq; ChIP-seq; RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR; RT-RT-qPCR; Western blot; CRISPRi (shRNA); Immunofluorescence |
About Target Gene
| Target gene : | Nfatc1 |
About TF
| TF name : | Nfatc1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Nfatc1 | AP-1 transcription factor network | pid | 71 |
| Nfatc1 | BCR signaling pathway | pid | 70 |
| Nfatc1 | Ca2+ pathway | reactome | 62 |
| Nfatc1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Nfatc1 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| Nfatc1 | CLEC7A (Dectin-1) induces NFAT activation | reactome | 13 |
| Nfatc1 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| Nfatc1 | FCERI mediated Ca+2 mobilization | reactome | 41 |
| Nfatc1 | Glucocorticoid receptor regulatory network | pid | 85 |
| Nfatc1 | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| Nfatc1 | RANKL | netpath | 84 |
| Nfatc1 | Role of Calcineurin-dependent NFAT signaling in lymphocytes | pid | 54 |
| Nfatc1 | Signaling by Wnt | reactome | 10 |
| Nfatc1 | TCR | netpath | 261 |
| Nfatc1 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| Nfatc1 | Wnt signaling pathway | panther | 250 |
| Nfatc1 | Wnt signaling pathway | kegg | 135 |
| Nfatc1 | Axon guidance | kegg | 126 |
| Nfatc1 | VEGF signaling pathway | kegg | 70 |
| Nfatc1 | Natural killer cell mediated cytotoxicity | kegg | 125 |
| Nfatc1 | T cell receptor signaling pathway | kegg | 105 |
| Nfatc1 | B cell receptor signaling pathway | kegg | 70 |
| Nfatc1 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| Nfatc1 | Hs_TLR4_Signaling_and_Tolerance_WP3851_90114 | wikipathways | 8 |
| Nfatc1 | Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 | wikipathways | 60 |
| Nfatc1 | Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 | wikipathways | 26 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03279 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03280 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03282 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03283 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
Expression of Target Genes for the Enhancer