About Enhancer
| Enhancer ID: | E_03280 |
| Species: | Mus musculus |
| Position : | chr18:87758000-87762000   |
| Year: | 2024 |
| Title: | Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | proliferative vitreoretinopathy |
| PMID: | 39183203 |
| MONDO: | MONDO:0700115 |
| Tissue: | retina |
| Tissue Ontology ID: | UBERON:0000966 |
| Cell Source: | Primary retinal pigment epithelium (RPE) cells |
| Cell Type: | retinal pigment epithelial cell |
| Cell Ontology ID: | CL:0002586 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ATAC-seq; ChIP-seq; RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR; RT-RT-qPCR; Western blot; CRISPRi (shRNA); Immunofluorescence |
About Target Gene
| Target gene : | Nfatc1 |
About TF
| TF name : | Ets1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Ets1 | Angiogenesis | panther | 141 |
| Ets1 | Angiopoietin receptor Tie2-mediated signaling | pid | 50 |
| Ets1 | AP-1 transcription factor network | pid | 71 |
| Ets1 | BCR signaling pathway | pid | 70 |
| Ets1 | C-MYB transcription factor network | pid | 87 |
| Ets1 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| Ets1 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| Ets1 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| Ets1 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| Ets1 | HIF-1-alpha transcription factor network | pid | 67 |
| Ets1 | HIF-2-alpha transcription factor network | pid | 34 |
| Ets1 | IL2 | netpath | 81 |
| Ets1 | IL4-mediated signaling events | pid | 66 |
| Ets1 | IL4 | netpath | 75 |
| Ets1 | Oncogene Induced Senescence | reactome | 30 |
| Ets1 | PDGF signaling pathway | panther | 113 |
| Ets1 | Ras Pathway | panther | 69 |
| Ets1 | Signaling events mediated by focal adhesion kinase | pid | 63 |
| Ets1 | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | pid | 80 |
| Ets1 | TGF_beta_Receptor | netpath | 220 |
| Ets1 | VEGF signaling pathway | panther | 54 |
| Ets1 | MAPK signaling pathway - fly | kegg | 16 |
| Ets1 | Dorso-ventral axis formation | kegg | 25 |
| Ets1 | Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 | wikipathways | 51 |
| Ets1 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| Ets1 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| Ets1 | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
| Ets1 | Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 | wikipathways | 71 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03279 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03281 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03282 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03283 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
Expression of Target Genes for the Enhancer