About Enhancer
| Enhancer ID: | E_03279 |
| Species: | Mus musculus |
| Position : | chr18:87758000-87762000   |
| Year: | 2024 |
| Title: | Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | proliferative vitreoretinopathy |
| PMID: | 39183203 |
| MONDO: | MONDO:0700115 |
| Tissue: | retina |
| Tissue Ontology ID: | UBERON:0000966 |
| Cell Source: | Primary retinal pigment epithelium (RPE) cells |
| Cell Type: | retinal pigment epithelial cell |
| Cell Ontology ID: | CL:0002586 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ATAC-seq; ChIP-seq; RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR; RT-RT-qPCR; Western blot; CRISPRi (shRNA); Immunofluorescence |
About Target Gene
| Target gene : | Nfatc1 |
About TF
| TF name : | Creb5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Creb5 | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | panther | 126 |
| Creb5 | Transcription regulation by bZIP transcription factor | panther | 42 |
| Creb5 | Vasopressin-regulated water reabsorption | kegg | 35 |
| Creb5 | Huntington's disease | kegg | 182 |
| Creb5 | Prostate cancer | kegg | 85 |
| Creb5 | Hs_MFAP5-mediated_ovarian_cancer_cell_motility_and_invasiveness_WP3301_87836 | wikipathways | 5 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03280 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03281 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03282 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
| E_03283 | chr18:87758000-87762000 | retina | retinal pigment epithelial cell | proliferative vitreoretinopathy |
Expression of Target Genes for the Enhancer