About Enhancer
| Enhancer ID: | E_03248 |
| Species: | Mus musculus |
| Position : | chr11:112769652-112770944   |
| Year: | 2017 |
| Title: | Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 28045957 |
| Tissue: | testis |
| Tissue Ontology ID: | UBERON:0000473 |
| Cell Source: | primary XY fetal gonadal somatic cells |
| Cell Type: | Sertoli cell precursor |
| Experiment Type: | In vivo enhancer loss-of-function; developmental enhancer assay |
| Low Throughput Method: | CRISPR-Cas9 TESCO deletion; qRT-PCR; immunofluorescence; histology; gonadal phenotyping; CRISPR-Cas9 |
About Target Gene
| Target gene : | Sox9 |
About TF
| TF name : | Sox9 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox9 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sox9 | TGF_beta_Receptor | netpath | 220 |
| Sox9 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| Sox9 | Hs_Spinal_Cord_Injury_WP2431_87678 | wikipathways | 21 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer