About Enhancer
| Enhancer ID: | E_03233 |
| Species: | Mus musculus |
| Position : | chr10:90723100-90723900   |
| Year: | 2019 |
| Title: | CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | obesity |
| PMID: | 30545847 |
| MONDO: | MONDO:0011122 |
| Tissue: | hypothalamus |
| Tissue Ontology ID: | UBERON:0001898 |
| Cell Source: | in vivo mouse hypothalamus |
| Cell Type: | hypothalamic neuron |
| Experiment Type: | Enhancer activation assay; In vivo functional perturbation assay |
| High Throughput Method: | RNA-seq; ChIP-seq |
| Low Throughput Method: | CRISPRa/dCas9-VP64 enhancer activation; AAV delivery; RT-qPCR; body-weight and feeding phenotyping |
About Target Gene
| Target gene : | Sim1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer