About Enhancer
| Enhancer ID: | E_03228 |
| Species: | Mus musculus |
| Position : | chr2:109689202-109690258   |
| Year: | 2024 |
| Title: | An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | obesity |
| PMID: | 38228888 |
| MONDO: | MONDO:0011122 |
| Tissue: | amygdala |
| Tissue Ontology ID: | UBERON:0001876 |
| Cell Source: | Female BE5.1KO mouse amygdala tissue |
| Experiment Type: | Functional perturbation assay; Target-gene expression assay; In vivo phenotypic validation; Endogenous enhancer perturbation; Disease-variant functional analysis; In vivo functional validation |
| High Throughput Method: | eQTL analysis; GWAS |
| Low Throughput Method: | CRISPR-Cas9 BE5.1 deletion; qRT-PCR; PCR genotyping; Sanger sequencing; CRISPR off-target validation; Elevated zero maze; Marble-burying test; Diazepam rescue; CRISPR-Cas9 endogenous deletion/editing; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | Bdnf-as |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer