Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_03217
Species: Mus musculus
Position : chr10:52388022-52388224
Year: 2014
Title: A regulatory network controls nephrocan expression and midgut patterning.
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
PMID:  25209250
Cell Source: P19
CVCL ID: CVCL_2153
Experiment Type: Enhancer activity assay; TF-binding/chromatin assay; Endogenous enhancer perturbation
Low Throughput Method: Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion; EMSA/gel-shift assay
About Target Gene
Target gene : Nepn
About TF
TF name : Sox17
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Sox17 Deactivation of the beta-catenin transactivating complex reactome 42
Sox17 Wnt signaling pathway kegg 135
Sox17 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Enhancer Associated Network
Overlapping Enhancers (mm10) 4 found
Enhancer ID Position Tissue Cell Disease
E_03250 chr10:52386564-52388864 definitive endoderm endodermal cell NA
E_03184 chr10:52388022-52388224 definitive endoderm malignant cell NA
E_03185 chr10:52388022-52388224 definitive endoderm malignant cell NA
E_03216 chr10:52388022-52388224 NA NA NA
Expression of Target Genes for the Enhancer