About Enhancer
| Enhancer ID: | E_03199 |
| Species: | Mus musculus |
| Position : | chr3:94294960-94295960   |
| Year: | 2022 |
| Title: | Transcription factor ROR汐 enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element |
| Genome Build: | mm39 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 36243007 |
| Tissue: | small intestine |
| Tissue Ontology ID: | UBERON:0002108 |
| Cell Source: | Primary small-intestinal lamina propria tissue-resident Th17 cells |
| Cell Type: | T-helper 17 cell |
| Cell Ontology ID: | CL:0000899 |
| Experiment Type: | Rorc CNS11/+11-kb cis-regulatory element; ROR污t occupancy/feed-forward regulation; in vivo enhancer-reporter deletion and lineage-maintenance validation; exact 1001-bp CNS11 interval independently validated by PMID 41739921 |
| High Throughput Method: | RNA-seq; ATAC-seq; ROR汐 ChIP-seq; ROR污t ChIP-seq |
| Low Throughput Method: | BAC/transgenic Rorc reporter; +11-kb element deletion reporter; Rora conditional deletion; RORE CRISPR editing; ChIP-qPCR; RT-qPCR; flow cytometry; EAE/peripheral inflammatory challenge |
About Target Gene
| Target gene : | Rorc |
About TF
| TF name : | Rorc |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Rorc | Nuclear Receptor transcription pathway | reactome | 51 |
Enhancer Associated Network
Overlapping Enhancers (mm39)
12 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02392 | chr3:94294960-94295960 | small intestine | type 17 immune cell | NA |
| E_02393 | chr3:94294960-94295960 | small intestine | type 17 immune cell | NA |
| E_02394 | chr3:94294960-94295960 | small intestine | type 17 immune cell | NA |
| E_03196 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03197 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03198 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03219 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03220 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03221 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03222 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03223 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03224 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
Expression of Target Genes for the Enhancer