About Enhancer
| Enhancer ID: | E_03188 |
| Species: | Mus musculus |
| Position : | chr5:107680655-107682655   |
| Year: | 2013 |
| Title: | The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 24014243 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Mysm1-deficient HSCs |
| Cell Type: | hematopoietic stem cell |
| Cell Ontology ID: | CL:0000037 |
| Experiment Type: | Epigenetic enhancer regulation; TF occupancy; functional transactivation; Endogenous enhancer perturbation; In vivo functional validation |
| High Throughput Method: | ChIP-seq / expression profiling |
| Low Throughput Method: | ChIP-qPCR; enhancer reporter assay; TF transactivation; RT-qPCR; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | Gfi1 |
About TF
| TF name : | Gata2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata2 | AP-1 transcription factor network | pid | 71 |
| Gata2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata2 | HIF-1-alpha transcription factor network | pid | 67 |
| Gata2 | IL3 | netpath | 84 |
| Gata2 | Regulation of Androgen receptor activity | pid | 54 |
| Gata2 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata2 | Signaling events mediated by HDAC Class II | pid | 58 |
| Gata2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03189 | chr5:107680655-107682655 | bone marrow | hematopoietic stem cell | NA |
| E_03190 | chr5:107680655-107682655 | bone marrow | hematopoietic stem cell | NA |
| E_03191 | chr5:107680655-107682655 | bone marrow | hematopoietic stem cell | NA |
| E_03259 | chr5:107680655-107682655 | blood / hematopoietic system | T cell | NA |
| E_03260 | chr5:107680655-107682655 | blood / hematopoietic system | T cell | NA |
Expression of Target Genes for the Enhancer