About Enhancer
| Enhancer ID: | E_03185 |
| Species: | Mus musculus |
| Position : | chr10:52388022-52388224   |
| Year: | 2014 |
| Title: | A regulatory network controls nephrocan expression and midgut patterning. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25209250 |
| Tissue: | definitive endoderm |
| Tissue Ontology ID: | UBERON:0005439 |
| Cell Source: | P19 |
| CVCL ID: | CVCL_2153 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional cis-element perturbation assay; In vivo functional validation |
| Low Throughput Method: | Deletion-mapping luciferase assay; SOX17 site-A mutagenesis/deletion; EMSA; Sox17 perturbation; RT-qPCR; In vivo phenotyping |
About Target Gene
| Target gene : | Nepn |
About TF
| TF name : | Sox17 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox17 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sox17 | Wnt signaling pathway | kegg | 135 |
| Sox17 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
4 found
Expression of Target Genes for the Enhancer