About Enhancer
| Enhancer ID: | E_03166 |
| Species: | Mus musculus |
| Position : | chr10:50623698-50625698   |
| Year: | 2019 |
| Title: | CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Haploinsufficiency |
| PMID: | 30545847 |
| Cell Source: | Hypothalamus |
| Experiment Type: | TF-binding/chromatin assay; Endogenous enhancer perturbation; Genetic-variant functional analysis; In vivo functional validation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq; ATAC-seq |
| Low Throughput Method: | CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; RT-qPCR/qPCR; Transgenic/LacZ assay |
About Target Gene
| Target gene : | Sim1 |
About TF
| TF name : | Sim1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer