About Enhancer
| Enhancer ID: | E_03160 |
| Species: | Mus musculus |
| Position : | chr8:120777048-120777744   |
| Year: | 2019 |
| Title: | An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 31406377 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | common dendritic cell progenitor / pre-cDC1 |
| Cell Type: | dendritic cell progenitor |
| Experiment Type: | Stage-specific enhancer assay; enhancer genetic perturbation; E-box mutagenesis |
| High Throughput Method: | Single-cell RNA-seq; ATAC-seq |
| Low Throughput Method: | Enhancer reporter; E-box mutagenesis; genetic epistasis; flow cytometry; enhancer-null mouse analysis |
About Target Gene
| Target gene : | Irf8 |
About TF
| TF name : | Tcf3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tcf3 | CDO in myogenesis | reactome | 29 |
| Tcf3 | ID | netpath | 38 |
| Tcf3 | Notch-mediated HES/HEY network | pid | 48 |
| Tcf3 | Notch | netpath | 76 |
| Tcf3 | p38 signaling mediated by MAPKAP kinases | pid | 21 |
| Tcf3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Tcf3 | Wnt | netpath | 118 |
| Tcf3 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
3 found
Expression of Target Genes for the Enhancer