About Enhancer
| Enhancer ID: | E_03147 |
| Species: | Mus musculus |
| Position : | chr16:95439106-95439643   |
| Year: | 2011 |
| Title: | ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 21536859 |
| MONDO: | MONDO:0004963 |
| Tissue: | thymus |
| Tissue Ontology ID: | UBERON:0002390 |
| Cell Source: | human T-ALL cells |
| Cell Type: | hematopoietic stem/progenitor and T-lineage leukemia cells |
| Experiment Type: | Enhancer reporter/transgenic validation; leukemia regulatory mechanism |
| High Throughput Method: | ChIP-seq/chromatin occupancy profiling |
| Low Throughput Method: | reporter assay; transgenic enhancer assay; TF-binding validation; leukemia growth/transformation assays |
About Target Gene
| Target gene : | Erg |
About TF
| TF name : | Gata3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata3 | C-MYB transcription factor network | pid | 87 |
| Gata3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Gata3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata3 | Glucocorticoid receptor regulatory network | pid | 85 |
| Gata3 | IL27-mediated signaling events | pid | 26 |
| Gata3 | Notch signaling pathway | pid | 58 |
| Gata3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Gata3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Gata3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
19 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03128 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03129 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03130 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03131 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03132 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03133 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03134 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03135 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03136 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03137 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03138 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03139 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03140 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03141 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03142 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03143 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03144 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03145 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03146 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer