About Enhancer
| Enhancer ID: | E_03132 |
| Species: | Mus musculus |
| Position : | chr16:95439106-95439643   |
| Year: | 2011 |
| Title: | ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 21536859 |
| MONDO: | MONDO:0004963 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | mouse hematopoietic enhancer reporter/transgenic models |
| Cell Type: | hematopoietic stem/progenitor and T-lineage leukemia cells |
| Experiment Type: | Enhancer reporter/transgenic validation; leukemia regulatory mechanism |
| High Throughput Method: | ChIP-seq/chromatin occupancy profiling |
| Low Throughput Method: | reporter assay; transgenic enhancer assay; TF-binding validation; leukemia growth/transformation assays |
About Target Gene
| Target gene : | Erg |
About TF
| TF name : | Lyl1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Lyl1 | Hs_TYROBP_Causal_Network_WP3945_90843 | wikipathways | 54 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
19 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03128 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03129 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03130 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03131 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03133 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03134 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03135 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03136 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03137 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03138 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03139 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03140 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03141 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03142 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03143 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03144 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03145 | chr16:95439106-95439643 | bone marrow | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03146 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
| E_03147 | chr16:95439106-95439643 | thymus | hematopoietic stem/progenitor and T-lineage leukemia cells | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer