About Enhancer
| Enhancer ID: | E_03127 |
| Species: | Mus musculus |
| Position : | chr8:124371000-124371500   |
| Year: | 2019 |
| Title: | An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 31406377 |
| Tissue: | spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | Mature cDC1 |
| Cell Type: | conventional dendritic cell |
| Cell Ontology ID: | CL:0000990 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ATAC-seq, ChIP-seq, RNA-seq; single-cell RNA-seq; RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | Irf8 |
About TF
| TF name : | Irf8 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Irf8 | GMCSF-mediated signaling events | pid | 38 |
| Irf8 | Interferon alpha/beta signaling | reactome | 67 |
| Irf8 | Interferon gamma signaling | reactome | 88 |
| Irf8 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Irf8 | Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 | wikipathways | 10 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03126 | chr8:124371000-124371500 | spleen | conventional dendritic cell | NA |
Expression of Target Genes for the Enhancer