About Enhancer
| Enhancer ID: | E_03097 |
| Species: | Mus musculus |
| Position : | chr6:122700483-122702483   |
| Year: | 2014 |
| Title: | Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25223790 |
| Cell Source: | Embryonic Stem Cell |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Endogenous enhancer perturbation |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Nanog |
About TF
| TF name : | Sox2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Sox2 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Sox2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Sox2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Sox2 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
| Sox2 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| Sox2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
13 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_05222 | chr6:122696853-122708211 | NA | NA | NA |
| E_05223 | chr6:122696853-122708211 | NA | NA | NA |
| E_05224 | chr6:122696853-122708211 | NA | NA | NA |
| E_05225 | chr6:122696853-122708211 | NA | NA | NA |
| E_05226 | chr6:122696853-122708211 | NA | NA | NA |
| E_03043 | chr6:122698567-122721126 | embryo | mouse embryonic stem cell | NA |
| E_03094 | chr6:122700483-122702483 | NA | NA | NA |
| E_03095 | chr6:122700483-122702483 | NA | NA | NA |
| E_03096 | chr6:122700483-122702483 | NA | NA | NA |
| E_03117 | chr6:122702344-122703335 | embryo | embryonic stem cell | NA |
| E_03118 | chr6:122702344-122703335 | embryo | embryonic stem cell | NA |
| E_03119 | chr6:122702344-122703335 | epiblast (generic) | epiblast cell | NA |
| E_03120 | chr6:122702344-122703335 | epiblast (generic) | epiblast cell | NA |
Expression of Target Genes for the Enhancer