About Enhancer
| Enhancer ID: | E_03043 |
| Species: | Mus musculus |
| Position : | chr6:122698567-122721126   |
| Year: | 2025 |
| Title: | Enhancer cooperativity can compensate for loss of activity over large genomic distances. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 39626663 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Mouse Embryonic Stem Cells (v6.5) |
| Cell Type: | mouse embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq; ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay; Fluorescent Reporter Assay (mCherry); Flow-FISH; RT-RT-qPCR |
About Target Gene
| Target gene : | Nanog |
About TF
| TF name : | Nanog |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Nanog | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Nanog | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Nanog | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
14 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_05222 | chr6:122696853-122708211 | NA | NA | NA |
| E_05223 | chr6:122696853-122708211 | NA | NA | NA |
| E_05224 | chr6:122696853-122708211 | NA | NA | NA |
| E_05225 | chr6:122696853-122708211 | NA | NA | NA |
| E_05226 | chr6:122696853-122708211 | NA | NA | NA |
| E_03094 | chr6:122700483-122702483 | NA | NA | NA |
| E_03095 | chr6:122700483-122702483 | NA | NA | NA |
| E_03096 | chr6:122700483-122702483 | NA | NA | NA |
| E_03097 | chr6:122700483-122702483 | NA | NA | NA |
| E_03117 | chr6:122702344-122703335 | embryo | embryonic stem cell | NA |
| E_03118 | chr6:122702344-122703335 | embryo | embryonic stem cell | NA |
| E_03119 | chr6:122702344-122703335 | epiblast (generic) | epiblast cell | NA |
| E_03120 | chr6:122702344-122703335 | epiblast (generic) | epiblast cell | NA |
| E_04410 | chr6:122717768-122722768 | embryo | mouse embryonic stem cell | NA |
Expression of Target Genes for the Enhancer