About Enhancer
| Enhancer ID: | E_02_0989 |
| Species: | human |
| Position : | chr11:5293686-5294250   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 12861010 |
| Enhancer experiment: | PCR,DNaseI-seq |
| Enhancer experiment description: | We have also found DNase I HSs at kb -85.5 (HS-85.5) and -84.5 in mouse, but there is no corresponding se_x0002_quence or structure in human for these HSs.By comparison,neither the active _x0002_maj-globin gene promoter nor a region located ~1 kb from HS5 shows significant enrichment. HS-85.5 exhibits a modest (twofold) enrichment. |
About Target gene
| Target gene : | LOC110006319(LOC110006319) |
| Strong evidence: | -- |
| Less strong evidence: | DNaseI-seq,Southern blot,PCR |
| Target gene experiment description: | In ery_x0002_throid cells, the active _x0002_-globin locus contains several DNase I HSs, which have been shown to map to sequences with regu_x0002_latory functionIn addition, histone hyperacetylation anddimethylation of histone H3 K4 are not uniform features of the nuclease-sensitive mouse _x0001_-globin domain but rather define distinct subdomains within it. Our results reveal a complex chromatin landscape for the active _x0001_-globin locus and illustrate the complexity of broad structural changes that accompany gene activation. |
About TF
| TF name : | CTCF(MRD21) |
| TF experiment: | ChIP |
| TF experiment description: | To determine whether CTCF binds to these sequences in vivo, we performed ChIP analysis using antibodies to CTCF. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene