About Enhancer
| Enhancer ID: | E_02_0973 |
| Species: | human |
| Position : | chr1:226065482-226067482   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 21419113 |
| Enhancer experiment: | PCR,Transgenic mice,Immunostaining |
| Enhancer experiment description: | We have now identified a transcriptional enhancer (ANE) in the human LEFTY1 gene that exhibits marked L>R asymmetric activity in perinodal cells of the mouse embryos.the enhancer activity of each fragment was examined in transgenic mouse embryos. |
About Target gene
| Target gene : | LEFTY1(LEFTB,LEFTYB) |
| Strong evidence: | -- |
| Less strong evidence: | PCR,Transgenic mice,Immunostaining |
| Target gene experiment description: | We have now identified a transcriptional enhancer (ANE) in the human LEFTY1 gene that exhibits marked L>R asymmetric activity in perinodal cells of the mouse embryos. |
About TF
| TF name : | FOXH1(FAST-1,FAST1) |
| TF experiment: | X-Gal Staining Assay |
| TF experiment description: | The approximate location of FoxH1 binding sites is indicated by red ovals. Restriction sites: E, EcoRI; Bam, BamHI; BgI, BglI; BX, BstXI; BgII, BglII; Sma, SmaI; Xb, XbaI; Sac, SacI. (BE) Ventral views of X-galstained embryos harboring the indicated lacZ transgenes. (FI) Magnified views of the node region of X-galstained embryos harboring hNPE7.5-lacZ. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXH1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| FOXH1 | Signaling by Activin | reactome | 11 |
| FOXH1 | Signaling by NODAL | reactome | 19 |
| FOXH1 | TGF-beta signaling pathway | panther | 88 |
| FOXH1 | TGF_beta_Receptor | netpath | 220 |
| FOXH1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| FOXH1 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| FOXH1 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene