About Enhancer
| Enhancer ID: | E_02_0968 |
| Species: | human |
| Position : | chr21:39823183-39825183   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | T-cell acute lymphoblastic leukemia |
| Pubmed ID: | 21536859 |
| Enhancer experiment: | Luciferase Reporter Assay,PCR,ChIP,ChIP-PCR,ChIP-seq |
| Enhancer experiment description: | The ERG stem cell enhancer is active in human T-cell progenitors and in T-ALL.Graphs at right show these peaks of enrichment confirmed by ChIP-PCR. |
About Target gene
| Target gene : | ERG (erg-3,p55) |
| Strong evidence: | q3C |
| Less strong evidence: | qPCR,ChIP-PCR |
| Target gene experiment description: | Taken together, these results show that genomic sequences in the human ERG locus corresponding to the mouse Erg +85 enhancer are in an active configuration in CD34+ stem/progenitors, pro-T, and T-ALL cells. |
About TF
| TF name : | GATA2(DCML,IMD21,MONOMAC,NFE1B)LMO2(LMO-2,RBTN2,RBTNL1,RHOM2,TTG2)SCL(SCL)LYL1(bHLHa18) |
| TF experiment: | ChIP-PCR |
| TF experiment description: | ChIP-PCR analysis of TF binding. The enhancer has active chromatin marks (AcH3) in 416B blood progenitors as well as in T-ALL cells. There is strong LMO2 binding in all cell types, whereas SCL and LYL1 enrichments are more pronounced in T-ALL cells. The Ets factors, FLI1 and ERG, are also enriched in T-ALL cells. Consistent with their expression profiles, Gata2 is enriched at the _x0001_85 enhancer in 416B progenitors, whereas GATA3 is enriched in T-ALL cells. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
| LYL1 | Hs_TYROBP_Causal_Network_WP3945_90843 | wikipathways | 54 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene