About Enhancer
| Enhancer ID: | E_02_0959 |
| Species: | human |
| Position : | chr8:117978845-117979466   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | Type 2 diabetes mellitus |
| Pubmed ID: | 21798992 |
| Enhancer experiment: | Luciferase Reporter Assay,PCR,Transfection |
| Enhancer experiment description: | we have identified a conserved islet beta cell-specific enhancer in SLC30A8 intron 2 (Figs. 4 & 5). |
About Target gene
| Target gene : | SLC30A8(ZNT8,ZnT-8),SLC30A8(ZNT8,ZnT-8) |
| Strong evidence: | -- |
| Less strong evidence: | Luciferase Reporter Assay,PCR,Transfection |
| Target gene experiment description: | To determine whether the +16579 and +16954 region of intron 2 in the human SLC30A8 gene also represents a transcriptional enhancer, this region was isolated using PCR and ligated 5' of the ?150/+3 G6PC2-luciferase fusion gene described above. Luciferase expression directed by this fusion gene was then analyzed by transient transfection of ?TC-3 and ?TC-6 cells.;To determine whether the +16579 and +16954 region of intron 2 in the human SLC30A8 gene also represents a transcriptional enhancer, this region was isolated using PCR and ligated 5' of the ?150/+3 G6PC2-luciferase fusion gene described above. Luciferase expression directed by this fusion gene was then analyzed by transient transfection of ?TC-3 and ?TC-6 cells. |
About TF
| TF name : | ---- |
| TF experiment: | -- |
| TF experiment description: | --;-- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | rs62510556 |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene