About Enhancer
| Enhancer ID: | E_02_0954 |
| Species: | mouse |
| Position : | chr11:32244715-32246895   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 22264824 |
| Enhancer experiment: | RT-PCR,ChIP,ChIP-seq |
| Enhancer experiment description: | Beyond this AFE the isoform structure appears identical to the full-length transcript. Interestingly, the AFE coincides with one of the known intragenic enhancers.First, we tested wild-type mouse tissues by RT-PCR to verify the existence of this alternative transcript. |
About Target gene
| Target gene : | Nprl3(Aag,CGTHBA,HS-26,HS-40,Mare,Phg,Prox1,m(alpha)RE) |
| Strong evidence: | -- |
| Less strong evidence: | RT-PCR,ChIP,ChIP-seq |
| Target gene experiment description: | Beyond this AFE the isoform structure appears identical to the full-length transcript. Interestingly, the AFE coincides with one of the known intragenic enhancers.First, we tested wild-type mouse tissues by RT-PCR to verify the existence of this alternative transcript. |
About TF
| TF name : | -- |
| TF experiment: | -- |
| TF experiment description: | -- |
About Function
| Enhancer function : | Intragenic Enhancers frequently act as alternative tissue_x005f_x0002_specific promoters producing a class of abundant,spliced, multiexonic poly(A)+ RNAs (meRNAs) which reflect the host genes structure. |
| Enhancer function experiment: | ChIP,RT-PCR,ChIP-seq |
| Enhancer function experiment description: |
To address this problem, we analyzed transcrip_x005f_x0002_tion of the Nprl3 gene after deleting its constitutive promoter. This revealed that intragenic Enhancers act as highly active, alternative tissue-specific promoters for the gene containing them. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene