About Enhancer
| Enhancer ID: | E_02_0936 |
| Species: | human |
| Position : | chr2:191834162-191834795   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 23598529 |
| Enhancer experiment: | Luciferase Reporter Assay,ChIP,PCR |
| Enhancer experiment description: | Our previous analysis of the STAT1 gene recognized a region downstream of the promoter and enhancer regions strongly repressing transcription of luciferase gene repor_x0002_ters (20). In the present study, we define an RE-1 element within this repressor region, to which REST bound and repressed transcription. In the absence of REST, transcriptional repression of the STAT1 gene was dramatically reduced. |
About Target gene
| Target gene : | STAT1(CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91) |
| Strong evidence: | -- |
| Less strong evidence: | Luciferase Reporter Assay,ChIP,PCR |
| Target gene experiment description: | Analysis of REST and STAT1 expression levels in human melanoma cells showed that REST is commonly expressed in melanomas and, together with transcription_x0002_al activation and chromatin immunoprecipitation (ChIP) assay, shows that REST negatively regulates STAT1 expression, contributing to the nonresponsiveness of mel_x0002_anomas to IFN. |
About TF
| TF name : | -- |
| TF experiment: | -- |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene