About Enhancer
| Enhancer ID: | E_02_0911 |
| Species: | human |
| Position : | chr8:128709135-128745673   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | Endometrial cancer |
| Pubmed ID: | 24512546 |
| Enhancer experiment: | ChIP,ChIP-PCR,ChIP-seq,qRT-PCR |
| Enhancer experiment description: | Interestingly, we showed that FOXA1 and AR more evidently bound to the MYC enhancer regions as compared to MYC promoter regions. These results could be attributed to other co-regulators involved in this binding process. Since TCF7L2, a protein mediating DNA looping for long-distance interactions of distal en_x0002_hancers and proximal promoters, physically interacts with FOXA1 and AR and mediates the transcription of MYC in breast cancer [19], future investigation will be needed to clarify which co-regulators are involved in FOXA1/AR binding to the enhancer regions upstream of MYC in EC cells. |
About Target gene
| Target gene : | MYC(MRTLC,bHLHe39,c-Myc),MYC(MRTLC,bHLHe39,c-Myc) |
| Strong evidence: | -- |
| Less strong evidence: | ChIP,ChIP-PCR,qRT-PCR |
| Target gene experiment description: | Our ChIP assays showed that both FOXA1 and AR could bind to all the five putative FOXA1-AR-binding regions in MFE-296 cells. More_x0002_over, both FOXA1 and AR bound most greatly to the Enh-1 (enhancer 1) region among the five binding regions (Figure 4D). Our ChIP data together with our co_x0002_immunoprecipitation data suggested that FOXA1 forming protein complex with AR might bind to FOXA1-AR over_x0002_lapping binding regions upstream of MYC, leading to MYC activation in EC cells.;Our ChIP assays showed that both FOXA1 and AR could bind to all the five putative FOXA1-AR-binding regions in MFE-296 cells. More_x0002_over, both FOXA1 and AR bound most greatly to the Enh-1 (enhancer 1) region among the five binding regions (Figure 4D). Our ChIP data together with our co_x0002_immunoprecipitation data suggested that FOXA1 forming protein complex with AR might bind to FOXA1-AR over_x0002_lapping binding regions upstream of MYC, leading to MYC activation in EC cells. |
About TF
| TF name : | FOXA1(HNF3A,TCF3A)AR(AIS8,DHTR,HUMARA,HYSP1,KD,NR3C4,SBMA,SMAX1,TFM,AR)FOXA1(HNF3A,TCF3A)AR(AIS8,DHTR,HUMARA,HYSP1,KD,NR3C4,SBMA,SMAX1,TFM,AR) |
| TF experiment: | ChIP,ChIP-PCR,ChIP-seq,qRT-PCR |
| TF experiment description: | Our ChIP assays showed that both FOXA1 and AR could bind to all the five putative FOXA1-AR-binding regions in MFE-296 cells. More_x0002_over, both FOXA1 and AR bound most greatly to the Enh-1 (Enhancer 1) region among the five binding regions.;Our ChIP assays showed that both FOXA1 and AR could bind to all the five putative FOXA1-AR-binding regions in MFE-296 cells. More_x0002_over, both FOXA1 and AR bound most greatly to the Enh-1 (Enhancer 1) region among the five binding regions. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene