About Enhancer
| Enhancer ID: | E_02_0905 |
| Species: | mouse |
| Position : | chr6:52199038-52200503   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 24705708 |
| Enhancer experiment: | EMSA,ChIP |
| Enhancer experiment description: | A 2.1-kb mesodermal (MES) enhancer important for Hoxa5 paraxial and lateral plate mesoderm expression in the cervico-upper thoracic region of the A-P axis is positioned 39 of the Hoxa5 gene. |
About Target gene
| Target gene : | Vegfa(MVCD1,VEGF,VPF),Vegfa(MVCD1,VEGF,VPF) |
| Strong evidence: | -- |
| Less strong evidence: | Transgenic mice,EMSA,qRT-PCR |
| Target gene experiment description: | A 1.5-kb XbaI-XbaI DNA fragment located in Hoxa4-Hoxa5 intergenic sequences at 3.0-kb upstream the Hoxa4 gene (positions +9351-bp to +10816-bp) was able to target Hoxa5 expression in lung and stomach.;A 1.5-kb XbaI-XbaI DNA fragment located in Hoxa4-Hoxa5 intergenic sequences at 3.0-kb upstream the Hoxa4 gene (positions +9351-bp to +10816-bp) was able to target Hoxa5 expression in lung and stomach. |
About TF
| TF name : | Yy1(DELTA,GADEVS,INO80S,NF-E1,UCRBP,YIN-YANG-1)Yy1(DELTA,GADEVS,INO80S,NF-E1,UCRBP,YIN-YANG-1) |
| TF experiment: | ChIP,qPCR |
| TF experiment description: | In summary, YY1 acts as a positive regulator of Hoxa5 lung, stomach and intestine expression during embryogenesis.;In summary, YY1 acts as a positive regulator of Hoxa5 lung, stomach and intestine expression during embryogenesis. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Yy1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Yy1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| Yy1 | E2F transcription factor network | pid | 77 |
| Yy1 | mTOR signaling pathway | pid | 66 |
| Yy1 | Notch-mediated HES/HEY network | pid | 48 |
| Yy1 | Notch | netpath | 76 |
| Yy1 | Notch signaling pathway | pid | 58 |
| Yy1 | p53 pathway | pid | 59 |
| Yy1 | Signaling events mediated by HDAC Class I | pid | 89 |
| Yy1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Yy1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| Yy1 | E2F transcription factor network | pid | 77 |
| Yy1 | mTOR signaling pathway | pid | 66 |
| Yy1 | Notch-mediated HES/HEY network | pid | 48 |
| Yy1 | Notch | netpath | 76 |
| Yy1 | Notch signaling pathway | pid | 58 |
| Yy1 | p53 pathway | pid | 59 |
| Yy1 | Signaling events mediated by HDAC Class I | pid | 89 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene