About Enhancer
| Enhancer ID: | E_02_0857 |
| Species: | human |
| Position : | chr7:114541370-114542201   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 26300977 |
| Enhancer experiment: | Luciferase Reporter Assay |
| Enhancer experiment description: | To test whether these regions could act as Enhancer elements we cloned them into a reporter construct in front of a minimal promoter and luciferase reporter gene.Element 1, which had multiple chromatin signatures characteristic of an enhancer, was able to act as a functional enhancer in both cell-lines (Fig. 1d).In HEK293 cells we observed a 3 fold increase of luciferase expression in comparison to the empty vector control.In SK-N-MC cells the luciferase expression increased nearly 7 fold as compared to the control. |
About Target gene
| Target gene : | FOXP2(CAGH44,SPCH1,TNRC10) |
| Strong evidence: | -- |
| Less strong evidence: | Luciferase Reporter Assay |
| Target gene experiment description: | To test whether these regions could act as Enhancer elements we cloned them into a reporter construct in front of a minimal promoter and luciferase reporter gene.Element 1, which had multiple chromatin signatures characteristic of an enhancer, was able to act as a functional enhancer in both cell-lines (Fig. 1d).In HEK293 cells we observed a 3 fold increase of luciferase expression in comparison to the empty vector control.In SK-N-MC cells the luciferase expression increased nearly 7 fold as compared to the control. |
About TF
| TF name : | -- |
| TF experiment: | -- |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene