About Enhancer
| Enhancer ID: | E_02_0856 |
| Species: | human |
| Position : | chr8:84899088-84902859   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 26303528 |
| Enhancer experiment: | ChIP |
| Enhancer experiment description: | We have shown by cotransfection and in vivo analyses that the small 950-bp region adjacent to the EKLF transcription start site is sufficient for tissue-restricted expression and wished to address whether the epigenetic profile of this region supports its importance. Database perusal of modified histone H3 interactions within the critical 950-bp region of the EKLF promoter/enhancer during hematopoiesis shows that levels of the H3K4me1 active enhancer mark increase exactly in parallel with activation of EKLF expression during hematopoiesis , that is, low within the hematopoietic repopulating cells and in myeloid (CMP and MPP) progenitors but high in MEPs and erythroblasts |
About Target gene
| Target gene : | Klf1(Eklf,Nan),Klf1(Eklf,Nan),Klf1(Eklf,Nan),Klf1(Eklf,Nan),Klf1(Eklf,Nan),Klf1(Eklf,Nan) |
| Strong evidence: | -- |
| Less strong evidence: | shRNA |
| Target gene experiment description: | Collectively, these studies demonstrate that DEK is required for EKLF expression and directly interacts in vitro and in vivo with its cognate site in the EKLF EHS1 Enhancer.;Collectively, these studies demonstrate that DEK is required for EKLF expression and directly interacts in vitro and in vivo with its cognate site in the EKLF EHS1 Enhancer.;Collectively, these studies demonstrate that DEK is required for EKLF expression and directly interacts in vitro and in vivo with its cognate site in the EKLF EHS1 Enhancer.;Collectively, these studies demonstrate that DEK is required for EKLF expression and directly interacts in vitro and in vivo with its cognate site in the EKLF EHS1 Enhancer.;Collectively, these studies demonstrate that DEK is required for EKLF expression and directly interacts in vitro and in vivo with its cognate site in the EKLF EHS1 Enhancer.;Collectively, these studies demonstrate that DEK is required for EKLF expression and directly interacts in vitro and in vivo with its cognate site in the EKLF EHS1 Enhancer. |
About TF
| TF name : | ------------ |
| TF experiment: | -- |
| TF experiment description: | --;--;--;--;--;-- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene