About Enhancer
| Enhancer ID: | E_02_0840 |
| Species: | human |
| Position : | chr7:117038917-117040917   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 26673704 |
| Enhancer experiment: | RT-qPCR,4C,ChIP,CRISPR/Cas9 |
| Enhancer experiment description: | Two pairs of gRNAs ?anking the ?20.9 kb CTCF site and the intron 11 enhancer core were identifed using the CRISPR Design Program |
About Target gene
| Target gene : | CFTR(ABC35,ABCC7,CF/MRP,MRP7,TNR-CFTR,dJ760C5.1\) |
| Strong evidence: | CRISPR/Cas9 |
| Less strong evidence: | -- |
| Target gene experiment description: | Here we use a combination of CRISPR/Cas9 editing of cis-regulatory elements and siRNA-mediated depletion of architectural proteins to determine the relative contribution of structural elements and enhancers to the higher order structure and expression of the CFTR locus. |
About TF
| TF name : | FOXA1(HNF3A,TCF3A)FOXA2(HNF3B,TCF3B)HNF1A(HNF-1A,HNF1,HNF4A,IDDM20,LFB1,MODY3,TCF-1,TCF1)CDX2(CDX-3/AS,CDX3,CDX2) |
| TF experiment: | 4C,ChIP,CRISPR/Cas9 |
| TF experiment description: | Approximately 1.2 encompass_x0002_ing the binding sites for critical transcription factors driving the intron 11 Enhancer (FOXA1/2,HNF1 and CDX2). |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene