About Enhancer
| Enhancer ID: | E_02_0781 |
| Species: | human |
| Position : | chr4:23811733-23994829   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Super-Enhancer |
| Disease: | Melanoma |
| Pubmed ID: | 28991225 |
| Enhancer experiment: | ChIP-seq |
| Enhancer experiment description: | We performed chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) using antibodies against H3K27ac and BRD4. |
About Target gene
| Target gene : | PPARGC1A(LEM6,PGC-1(alpha),PGC-1alpha,PGC-1v,PGC1,PGC1A,PPARGC1),PPARGC1A(LEM6,PGC-1(alpha),PGC-1alpha,PGC-1v,PGC1,PGC1A,PPARGC1) |
| Strong evidence: | -- |
| Less strong evidence: | ChIP-seq |
| Target gene experiment description: | We performed chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) using antibodies against H3K27ac and BRD4.;We performed chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) using antibodies against H3K27ac and BRD4. |
About TF
| TF name : | ---- |
| TF experiment: | -- |
| TF experiment description: | --;-- |
About Function
| Enhancer function : | BRD4 binding at super-enhancers that drive the expression of PGC-1? and SOX10 |
| Enhancer function experiment: | ChIP-seq,ChIP-qPCR |
| Enhancer function experiment description: |
We provide evidence for a direct role of BRD4 binding at super-enhancers that drive the expression of PGC-1? and SOX10, a transcription factor involved in melanocyte development. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene