About Enhancer
| Enhancer ID: | E_02_0780 |
| Species: | human |
| Position : | chr16:92625802-92627802   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | Leukaemia |
| Pubmed ID: | 29042628 |
| Enhancer experiment: | 4C-seq,ChIP |
| Enhancer experiment description: | 4C-seq in HPC-7 cells using the P1 and P2 promoters and the +24 enhancer as baits identified genomic interactions at Runx1 (Fig. 1a) |
About Target gene
| Target gene : | Runx1(BTEB2,CKLF,IKLF) |
| Strong evidence: | 4C-seq |
| Less strong evidence: | -- |
| Target gene experiment description: | Strikingly, the +24 enhancer in particular forms many significant interactions outside the Runx1 domain (Fig. 1b,d). Many of these long-range interactions are with other genes or gene promoters on mouse chromosome 16 (Fig. 2). |
About TF
| TF name : | -- |
| TF experiment: | -- |
| TF experiment description: | -- |
About Function
| Enhancer function : | known haematopoietic enhancers that are likely to be involved in regulating?Runx1?expression in haematopoietic progenitor cells. |
| Enhancer function experiment: | DNase I Hypersensitivity Assay,4C-seq,Hi-C |
| Enhancer function experiment description: |
These regions not only drive haematopoietic expression, but also physically connect with the Runx1-P1 promoter, lending confidence to the concept that they are bona fide regulators of Runx1 transcription. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene