About Enhancer
| Enhancer ID: | E_02_0740 |
| Species: | human |
| Position : | chr5:88714434-88716434   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Muscle wasting |
| Pubmed ID: | 32132110 |
| Enhancer experiment: | Immunohistochemistry, oil red O staining, Western blot, RT-qPCR |
| Enhancer experiment description: | g. Further, we identified the Myocyte enhancer factor 2 C (MEF2C) transcription factor as a key upstream activator of Myoc whose gain-of-function significantly deterred cancer-induced muscle wasting and dysfunction in a pre-clinical model of pancreatic ductal adenocarcinoma (PDAC). |
About Target gene
| Target gene : | MEF2C(5430401D19Rik,9930028G15Rik,AV011172,Mef2) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | g. Further, we identified the Myocyte enhancer factor 2 C (MEF2C) transcription factor as a key upstream activator of Myoc whose gain-of-function significantly deterred cancer-induced muscle wasting and dysfunction in a pre-clinical model of pancreatic ductal adenocarcinoma (PDAC). |
About TF
| TF name : | -- |
| TF experiment: | ???????O???Western blot?RT-QPCR |
| TF experiment description: | g. Further, we identified the Myocyte enhancer factor 2 C (MEF2C) transcription factor as a key upstream activator of Myoc whose gain-of-function significantly deterred cancer-induced muscle wasting and dysfunction in a pre-clinical model of pancreatic ductal adenocarcinoma (PDAC). |
About Function
| Enhancer function : | g. Further, we identified the Myocyte enhancer factor 2 C (MEF2C) transcription factor as a key upstream activator of Myoc whose gain-of-function significantly deterred cancer-induced muscle wasting and dysfunction in a pre-clinical model of pancreatic ductal adenocarcinoma (PDAC). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
g. Further, we identified the Myocyte enhancer factor 2 C (MEF2C) transcription factor as a key upstream activator of Myoc whose gain-of-function significantly deterred cancer-induced muscle wasting and dysfunction in a pre-clinical model of pancreatic ductal adenocarcinoma (PDAC). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene