About Enhancer
| Enhancer ID: | E_02_0732 |
| Species: | human |
| Position : | chr6:31572563-31574563   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 33028869 |
| Enhancer experiment: | qRT-PCR |
| Enhancer experiment description: | Further bioinformatic analysis, employing Ingenuity Pathway Analysis identifed signifcant enrichment in XAV-939-treated cells of functional categories and networks involved in TNF, NF?B, and STAT signaling. We identifed a Tankyrase inhibitor (XAV-939) as a powerful enhancer of osteoblastic diferentiation of hBMSC that may be useful as a therapeutic option for treating conditions associated with low bone formation. |
About Target gene
| Target gene : | TNF |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Further bioinformatic analysis, employing Ingenuity Pathway Analysis identifed signifcant enrichment in XAV-939-treated cells of functional categories and networks involved in TNF, NF?B, and STAT signaling. We identifed a Tankyrase inhibitor (XAV-939) as a powerful enhancer of osteoblastic diferentiation of hBMSC that may be useful as a therapeutic option for treating conditions associated with low bone formation. |
About TF
| TF name : | -- |
| TF experiment: | qRT-PCR |
| TF experiment description: | Further bioinformatic analysis, employing Ingenuity Pathway Analysis identifed signifcant enrichment in XAV-939-treated cells of functional categories and networks involved in TNF, NF?B, and STAT signaling. We identifed a Tankyrase inhibitor (XAV-939) as a powerful enhancer of osteoblastic diferentiation of hBMSC that may be useful as a therapeutic option for treating conditions associated with low bone formation. |
About Function
| Enhancer function : | Further bioinformatic analysis, employing Ingenuity Pathway Analysis identifed signifcant enrichment in XAV-939-treated cells of functional categories and networks involved in TNF, NF?B, and STAT signaling. We identifed a Tankyrase inhibitor (XAV-939) as a powerful enhancer of osteoblastic diferentiation of hBMSC that may be useful as a therapeutic option for treating conditions associated with low bone formation. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Further bioinformatic analysis, employing Ingenuity Pathway Analysis identifed signifcant enrichment in XAV-939-treated cells of functional categories and networks involved in TNF, NF?B, and STAT signaling. We identifed a Tankyrase inhibitor (XAV-939) as a powerful enhancer of osteoblastic diferentiation of hBMSC that may be useful as a therapeutic option for treating conditions associated with low bone formation. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene