About Enhancer
| Enhancer ID: | E_02_0680 |
| Species: | human |
| Position : | chr3:108040258-108042258   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Pulmonary fibrosis |
| Pubmed ID: | 32493933 |
| Enhancer experiment: | ATAC-seq,ChIP-seq,Q-PCR |
| Enhancer experiment description: | Using ATAC-seq and ChIP-seq, we found that acti_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x0002_vation of JUN rendered promoters and enhancers of CD47 and PD-L1 accessible. We furtherdetect increased IL-6 that amplified JUN-mediated CD47 enhancer activity and protein expression. |
About Target gene
| Target gene : | CD47(IAP,MER6,OA3) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Using ATAC-seq and ChIP-seq, we found that acti_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x0002_vation of JUN rendered promoters and enhancers of CD47 and PD-L1 accessible. We furtherdetect increased IL-6 that amplified JUN-mediated CD47 enhancer activity and protein expression. |
About TF
| TF name : | -- |
| TF experiment: | ATAC-seq,ChIP-seq,Q-PCR |
| TF experiment description: | Using ATAC-seq and ChIP-seq, we found that acti_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x0002_vation of JUN rendered promoters and enhancers of CD47 and PD-L1 accessible. We furtherdetect increased IL-6 that amplified JUN-mediated CD47 enhancer activity and protein expression. |
About Function
| Enhancer function : | Using ATAC-seq and ChIP-seq, we found that acti_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x0002_vation of JUN rendered promoters and enhancers of CD47 and PD-L1 accessible. We furtherdetect increased IL-6 that amplified JUN-mediated CD47 enhancer activity and protein expression. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Using ATAC-seq and ChIP-seq, we found that acti_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x0002_vation of JUN rendered promoters and enhancers of CD47 and PD-L1 accessible. We furtherdetect increased IL-6 that amplified JUN-mediated CD47 enhancer activity and protein expression. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene