About Enhancer
| Enhancer ID: | E_02_0662 |
| Species: | human |
| Position : | chrX:67541427-67543427   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Muscle invasive disease (muscle invasive disease) |
| Pubmed ID: | 31234917 |
| Enhancer experiment: | PCR, Western blot, gel electrophoresis |
| Enhancer experiment description: | ASC-J9? increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals. |
About Target gene
| Target gene : | AR,BCL2(Bcl-2,PPP1R50),BAX |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | ASC-J9? increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals.;The combined therapy increases the expression of the pro-apoptosis BAX gene and cell cycle inhibitor p21 gene, yet suppresses the expression of the pro-survival BCL2 gene in miBCa cells.;The combined therapy increases the expression of the pro-apoptosis BAX gene and cell cycle inhibitor p21 gene, yet suppresses the expression of the pro-survival BCL2 gene in miBCa cells. |
About TF
| TF name : | -- |
| TF experiment: | PCR,Western blot,???? |
| TF experiment description: | ASC-J9? increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals.;The combined therapy increases the expression of the pro-apoptosis BAX gene and cell cycle inhibitor p21 gene, yet suppresses the expression of the pro-survival BCL2 gene in miBCa cells.;The combined therapy increases the expression of the pro-apoptosis BAX gene and cell cycle inhibitor p21 gene, yet suppresses the expression of the pro-survival BCL2 gene in miBCa cells. |
About Function
| Enhancer function : | ASC-J9? increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
ASC-J9? increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene