About Enhancer
| Enhancer ID: | E_02_0655 |
| Species: | human |
| Position : | chr3:181709143-181711143   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Cancer (cancer) |
| Pubmed ID: | 31375262 |
| Enhancer experiment: | Gene knockdown, PCR, gel electrophoresis, Western blot |
| Enhancer experiment description: | Loss of neural differentiation is accom_x005f_x0002_panied by changes in gene expression, including loss of the neu_x0002_ral-specific factors SOX2 and SOX3 and the downstream targets PAX6 and SOX11. |
About Target gene
| Target gene : | SOX2(ANOP3,MCOPS3),PAX6,SOX11,SMARCA2,SMARCA4 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Loss of neural differentiation is accom_x005f_x0002_panied by changes in gene expression, including loss of the neu_x0002_ral-specific factors SOX2 and SOX3 and the downstream targets PAX6 and SOX11.;Loss of neural differentiation is accom_x005f_x0002_panied by changes in gene expression, including loss of the neu_x0002_ral-specific factors SOX2 and SOX3 and the downstream targets PAX6 and SOX11.;Loss of neural differentiation is accom_x005f_x0002_panied by changes in gene expression, including loss of the neu_x0002_ral-specific factors SOX2 and SOX3 and the downstream targets PAX6 and SOX11.;Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.;Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. |
About TF
| TF name : | -- |
| TF experiment: | ????,PCR,????,Western blot |
| TF experiment description: | Loss of neural differentiation is accom_x005f_x0002_panied by changes in gene expression, including loss of the neu_x0002_ral-specific factors SOX2 and SOX3 and the downstream targets PAX6 and SOX11.;Loss of neural differentiation is accom_x005f_x0002_panied by changes in gene expression, including loss of the neu_x0002_ral-specific factors SOX2 and SOX3 and the downstream targets PAX6 and SOX11.;Loss of neural differentiation is accom_x005f_x0002_panied by changes in gene expression, including loss of the neu_x0002_ral-specific factors SOX2 and SOX3 and the downstream targets PAX6 and SOX11.;Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.;Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. |
About Function
| Enhancer function : | Loss of neural differentiation is accom_x005f_x0002_panied by changes in gene expression, including loss of the neu_x0002_ral-specific factors SOX2 and SOX3 and the downstream targets PAX6 and SOX11. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Loss of neural differentiation is accom_x005f_x0002_panied by changes in gene expression, including loss of the neu_x0002_ral-specific factors SOX2 and SOX3 and the downstream targets PAX6 and SOX11. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene